The configuration of st is done by creating a custom config.h and (re)compiling the source code. To create a custom config.h, unpack the tarball, copy the file st-$version/config.def.h to st's port directory, and edit to suit your preferences. Then, when you call pkgmk in the st port directory, the custom config.h will be detected and copied into the source before compilation. I recommend that you save a copy your custom config.h some where other than the st port directory, so that your changes won't get nuked when updating ports or performing a prtsweep or prtwash (see opt/prt-utils for more information about those two). Another solution for customizing st is to create a custom and (preferably) private port that contains your custom config and also might include patches, such as from https://suckless.org/patches/.